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The external gills of an adult axolotl are not as efficient as fish gills because___________.


A) axolotls are slow swimmers and all fish swim fast to ventilate their gills
B) blood flows though the axolotl gills more slowly than through fish gills
C) axolotl gills are not highly branched
D) water flows over the axolotl gills at many different angles
E) axolotl gills are covered by thick layers of cells

F) A) and B)
G) D) and E)

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Four-year old Sammy is having a temper-tantrum. In a final attempt to get his way, he yells to his mom, "I'm gonna hold my breath 'til I die!" What is the primary reason that Sammy's mom is unconcerned by this statement?


A) As Sammy holds his breath, the increasing levels of carbon dioxide in his blood will lead to stimulation of the respiratory control center in his brain.
B) As Sammy holds his breath, the decreasing levels of oxygen in his blood will lead to stimulation of the respiratory control center in his brain.
C) Sammy is too young to hold his breath for more than 30 seconds.
D) It is impossible for Sammy to control the contraction of his diaphragm and intercostal muscles since they are made up of smooth muscle.

E) None of the above
F) C) and D)

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Under what circumstance would your body experience an increase in erythropoietin secretion?


A) after drinking 5 liters of water in just 2 hours
B) if you are suffering from dehydration
C) if you are suffering from hypertension
D) if you just moved from New York City to start training for a marathon in the 'Mile-High' city of Denver, Colorado
E) if your hematocrit is elevated above normal levels

F) A) and B)
G) D) and E)

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When diet and exercise has failed to produce any significant weight loss, some patients who are seriously overweight elect to have stomach surgery. A procedure galled gastric sleeve surgery removes more than half of the stomach, leaving a tube (or sleeve) about the size of a banana. Following gastric sleeve surgery, patients would have the least trouble ____.


A) eating carbohydrate-rich foods
B) eating protein-rich foods
C) eating large chunks of food of relatively hard consistency
D) eating large amounts of food at one time

E) A) and B)
F) A) and C)

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The benefit provided by all hearts with two atria is


A) that blood is pumped into body tissues at high pressure.
B) complete separation of oxygenated and deoxygenated blood.
C) there is an extra place to store blood when the animal is at rest.
D) that there are two muscular regions for pumping blood out of the heart to different organs.
E) not all the blood has to pass through both sides of the heart.

F) B) and E)
G) A) and E)

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The left ventricle in mammals is more muscular than the right ventricle because


A) the left ventricle is always contracting to maintain a systemic blood pressure.
B) the left ventricle has to pump blood throughout the body at high pressure.
C) the right ventricle only pumps blood into the right atrium.
D) the left ventricle pumps blood with a higher hematocrit than the blood that leaves the right ventricle.
E) the left ventricle pumps more total blood than the right ventricle.

F) A) and D)
G) C) and D)

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If each human lung contains about 300 million alveoli with a summed total surface area for gas exchange of 40 square meters, what is the approximate surface area of a single alveolus?


A) 133 square millimeters
B) 7.5 square micrometers
C) 750 square micrometers
D) 1.33 square micrometers
E) 7.5 square millimeters
F) 0.133 square millimeters

G) A) and E)
H) A) and B)

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The pancreas does NOT secrete ______.


A) chymotrypsin
B) bicarbonate
C) bile
D) lipase
E) amylase
F) glucagon

G) B) and D)
H) All of the above

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A major genetic cause of lung damage due to destruction of the alveolar walls is deficiency of the protein alpha-1 anti-trypsin (AAT) . AAT is an enzyme that inhibits the activity of another protein. What protein is most likely the normally-inhibited target of AAT?


A) collagen
B) carbonic anhydrase
C) elastin-specific protease
D) alpha and beta globulins
E) hemoglobin
F) albumin

G) A) and B)
H) B) and E)

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What is the likely outcome if you were able to force water through fish gills in the opposite direction to how it normally flows over the gills?


A) There would be no effect, and maximal oxygenation of blood would still occur.
B) The movement of carbon dioxide from the blood into the water would increase.
C) The direction of blood flow would reverse through the gills to compensate for the reversed direction of water flow.
D) Gas exchange would be inhibited and movement of oxygen into the blood would cease.
E) The blood's oxygen concentration would not be able to exceed 50%.

F) D) and E)
G) A) and B)

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Jim is suffering from congestive heart failure, in which blood flow is backed up in his lungs and excess fluid is escaping the blood and accumulating in his lung tissue. If untreated, increasing pulmonary edema will lead to death by suffocation. What is the most-likely cause of Jim's congestive heart failure?


A) Jim's right atrioventricular valve (tricuspid valve) is not closing properly.
B) Contraction of his left ventricle is not keeping up with contraction of his right ventricle.
C) Jim's pulmonary semilunar valve is not opening properly.
D) Jim's SA node is malfunctioning.
E) Contraction of his right atrium is not keeping up with contraction of his left atrium.

F) C) and D)
G) A) and D)

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Every winter, many individuals tragically die in their sleep due to faulty heaters that leak carbon monoxide (CO) during the night. How does CO poisoning lead to death?


A) CO inhibits the chemosensitive neurons in the aortic and carotid bodies.
B) CO coats the surfaces of the alveoli, preventing diffusion of oxygen into the blood.
C) CO binds more tightly to carbonic anhydrase than does carbon dioxide.
D) CO binds more tightly to hemoglobin than does oxygen.
E) CO binds to oxygen, and the CO-oxygen complex cannot bind to hemoglobin.

F) D) and E)
G) A) and B)

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In the blood clotting cascade mechanism, what is the first event that occurs following injury to a blood vessel?


A) conversion of fibrinogen to fibrin
B) fragmentation of a megakaryocyte to form platelets
C) aggregation of fibrin threads
D) secretion of fibrinogen into the blood
E) secretion of prothrombin into the blood

F) A) and D)
G) C) and D)

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Susie just squished a cockroach and its pale yellow hemolymph squirted out on the floor. If Susie analyzed the hemolymph, she would expect to find all of the following EXCEPT


A) cells that protect against foreign microbes.
B) ions.
C) water.
D) amino acids.
E) sugars.
F) hemoglobin.

G) E) and F)
H) B) and F)

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The villi of the small intestine are invaginations of the _____________.


A) mucosa only
B) submucosa and mucosa
C) mucosa, submucosa and serosa
D) serosa only
E) muscularis only
F) serosa, muscularis, submucosa and mucosa

G) E) and F)
H) C) and F)

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The cardiac output is the volume of blood that is pumped out of the ventricles of the heart in the time interval of one minute. What factor most limits a person's maximal increase in cardiac output during exercise?


A) the rate at which oxygen is delivered to the cardiac muscle cells
B) the time available to fill the heart chambers with blood as the heart rate increases
C) the time it takes for electrical impulses to reach all parts of the heart
D) the total amount of blood in an individual
E) the rate at which cardiac muscle contracts

F) B) and C)
G) B) and D)

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  In the above graph, if Bracket A represents the tidal volume and Bracket B represents the vital capacity, respectively, of a young man, what does Bracket C represent? A)  anatomical dead space B)  air that is not used for gas exchange C)  air that helps keep the alveoli inflated (open)  after forced exhalation D)  air from a previous breath that does not mix with newly-inhaled air of the next breath E)  air with a concentration of oxygen higher than that of air outside the body In the above graph, if Bracket A represents the tidal volume and Bracket B represents the vital capacity, respectively, of a young man, what does Bracket C represent?


A) anatomical dead space
B) air that is not used for gas exchange
C) air that helps keep the alveoli inflated (open) after forced exhalation
D) air from a previous breath that does not mix with newly-inhaled air of the next breath
E) air with a concentration of oxygen higher than that of air outside the body

F) A) and E)
G) A) and D)

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Blood returning to the left atrium of a frog heart has just come from ________________.


A) the lungs or the brain
B) the brain or the skin
C) the lungs only
D) the lungs or the skin
E) the skin only
F) the brain only

G) C) and D)
H) B) and D)

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The brachial artery is the major artery in your upper arm. The figure below shows the blood pressure in the brachial artery of an average young adult, as it oscillates between the systolic pressure (120 mm Hg) and the diastolic pressure (75 mm Hg) . The brachial artery is the major artery in your upper arm. The figure below shows the blood pressure in the brachial artery of an average young adult, as it oscillates between the systolic pressure (120 mm Hg)  and the diastolic pressure (75 mm Hg) .   Superimposed on the right side of the graph is a tracing of the pressure in the left ventricle, which drops to close to zero mm Hg during diastole. What prevents the blood pressure in the brachial artery from similarly dropping to almost zero during diastole? A)  Forceful closing of valves in the subclavian and brachial arteries propels the blood forward during diastole. B)  Recoil of elastic fibers in the aorta propels the blood forward during diastole. C)  Forceful closing of the aortic semilunar valve propels the blood forward during diastole. D)  Rhythmic contraction of smooth muscle tissue in the subclavian and brachial arteries propels the blood forward during diastole. E)  Inhaling and exhaling propels the blood forward during diastole. Superimposed on the right side of the graph is a tracing of the pressure in the left ventricle, which drops to close to zero mm Hg during diastole. What prevents the blood pressure in the brachial artery from similarly dropping to almost zero during diastole?


A) Forceful closing of valves in the subclavian and brachial arteries propels the blood forward during diastole.
B) Recoil of elastic fibers in the aorta propels the blood forward during diastole.
C) Forceful closing of the aortic semilunar valve propels the blood forward during diastole.
D) Rhythmic contraction of smooth muscle tissue in the subclavian and brachial arteries propels the blood forward during diastole.
E) Inhaling and exhaling propels the blood forward during diastole.

F) D) and E)
G) C) and D)

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  The above diagram shows four different types of transport proteins in the membranes of epithelial cells that line the small intestine. What protein most likely carries out coupled transport of both Na<sup>+</sup> and glucose in the overall process of glucose absorption? A)  1 (purple)  B)  2 (yellow)  C)  3 (blue)  D)  4 (green)  E)  none of the above The above diagram shows four different types of transport proteins in the membranes of epithelial cells that line the small intestine. What protein most likely carries out coupled transport of both Na+ and glucose in the overall process of glucose absorption?


A) 1 (purple)
B) 2 (yellow)
C) 3 (blue)
D) 4 (green)
E) none of the above

F) A) and C)
G) C) and D)

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