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When a segment of DNA duplicates,causing two copies of a gene to be present in the chromosome,the duplicate copy could possibly (Check all that apply)


A) lose function due to mutation.
B) become an ortholog.
C) gain a new function due to mutation.
D) become a pseudogene.
E) become a centromere.

F) B) and E)
G) A) and D)

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Many genes in the human genome are no longer expressed because mutations have introduced stop codons within the coding sequence or transposons have disrupted gene function.These genes are now considered


A) pseudogenes.
B) orthologs.
C) paralogs.
D) homologues.

E) All of the above
F) A) and C)

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Choose the true statements about the genomes of plants (especially Arabidopsis and rice) ,animals,and fungi.


A) Plants,animals,and fungi share most of the same genes for intermediary metabolism,genome replication,and protein synthesis.
B) "Plant" genes include those coding for photosynthetic pathways and morphology.
C) Plants generally have smaller genomes than those of animals and fungi.
D) Rice has fewer genes than humans.

E) B) and C)
F) C) and D)

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Choose the true statements about pseudogenes.


A) Premature stop codons can produce pseudogenes.
B) Missense mutations can produce pseudogenes.
C) Pseudogenes have DNA sequences very similar to a functional gene.
D) Pseudogenes result from horizontal gene transfer.

E) C) and D)
F) A) and B)

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Choose the true statements about the human and chimpanzee genomes.


A) A comparison of genomes confirms that humans and chimpanzees are closely related species.
B) Very few mutations differentiating the two genomes occur in coding DNA.
C) Some insertion-deletions (indels) lead to loss of function changes in the two genomes.
D) More similarity exists between the genomes of human and mouse than between human and chimpanzee.
E) The estimated genome sizes and number of genes is very different in humans and chimpanzees.

F) A) and B)
G) A) and C)

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Comparisons of human and mouse genomes reveals


A) they have widely different numbers of genes,and share only a few more genes than humans and pufferfish.
B) the differences between humans and mice are mainly the introns.
C) they have very little in common.
D) the genomes are very similar,with most of the genes unique to mice linked to size and shape.
E) the genomes are very similar,with most of the genes unique to mice linked to smell and reproduction.

F) A) and B)
G) C) and D)

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Using the sequencing results for genomes from each of the kingdoms,it is currently possible


A) to explore genetic differences between species very directly,examining DNA changes.
B) to build,from scratch,complex organisms with trans-kingdom genomes.
C) to sequence and build,from scratch,simple organisms with trans-kingdom genomes.
D) to design humans with a variety of inter-kingdom abilities built into their DNA.

E) B) and D)
F) A) and D)

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Gene inactivation is likely to produce


A) pseudogenes.
B) orthologs.
C) paralogs.
D) homologues.
E) horizontal gene transfer (HGT) .

F) A) and C)
G) None of the above

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The types of human genes most likely to be duplicated,resulting in multiple copies,are


A) genes controlling basic tissue development.
B) immune system genes.
C) genes for cell surface receptors.
D) genes for controlling basic metabolism.

E) B) and C)
F) A) and C)

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Which one of the following statements about horizontal gene transfer is false?


A) Horizontal gene transfer is also called lateral gene transfer.
B) Horizontal gene transfer involves hitchhiking genes from other species.
C) Horizontal gene transfer was common early in life,but is absent today.
D) Gene swapping is evident in the human genome.
E) The products of horizontal gene transfer often exist as transposons.

F) B) and C)
G) None of the above

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Choose the most influential contributing factor to the reduced sense of smell in humans compared with the other great apes.


A) pseudogenes
B) conservation of synteny
C) aneuploidy
D) one more chromosome in humans compared to the other great apes
E) number of olfactory receptor (OR) genes present in the genome

F) B) and C)
G) A) and E)

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Recent research has suggested that some pseudogenes and non-protein-coding DNA code for RNAs that affect transcription of coding regions.This suggests that


A) pseudogenes code for proteins.
B) non-protein-coding DNA has no function.
C) non-protein-coding DNA may regulate gene expression.
D) pseudogenes have no function.

E) A) and C)
F) B) and D)

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Genes are found in the same order for large stretches of the X chromosome in the rat and mouse genomes,indicating


A) occurrence of aneuploidy.
B) formation of pseudogenes.
C) conservation of synteny.
D) conservation of neoteny.

E) B) and C)
F) None of the above

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The protein-coding gene sequences in humans and chimpanzees


A) are vastly different.
B) are about 50% alike.
C) are about 80% alike.
D) are more than 99% alike.
E) are identical.

F) A) and C)
G) D) and E)

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